Reducevcf
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reducevcf is a tool to reduce the size of VCF files.
It will remove all lines where the alternative allele matches the reference allele. In most cases this will reduce the VCF to less than 1% of its original size.
Download
The latest version of reduce VCF is available for download from the GenomeView server.
Usage
Usage: java -jar reducevcf.jar [options]
-i <file> | --input <file> Input file -o <file> | --output <file> Output file -k | --keep Keep ambiguous calls
Example: java -jar reducevcf.jar -i myLargeVCFFile.vcf -o smallOutputFile.vcf